Figure 4.
Figure 4. Model outlining the roles of SHP-2, RAS, and NF1 in the granulocyte-macrophage colony-stimulating factor (GM-CSF) signal transduction pathway. In juvenile myelomonocytic leukemia (JMML), molecular alterations have been demonstrated in PTPN11 (the gene encoding SHP-2), RAS and NF1 in approximately 35%, 25% and 25% of patients, respectively.

Model outlining the roles of SHP-2, RAS, and NF1 in the granulocyte-macrophage colony-stimulating factor (GM-CSF) signal transduction pathway. In juvenile myelomonocytic leukemia (JMML), molecular alterations have been demonstrated inPTPN11(the gene encoding SHP-2),RASandNF1in approximately 35%, 25% and 25% of patients, respectively.

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