Gene expression profiling (GEP) model defines a high-risk disease and is not affected by presence of abnormal cytogenetics.

Left panel presents Kaplan-Meier curves for high-risk myeloma (high RAN/low ZHX-2/low CHC1L) and low-risk myeloma (all others). The right panel shows Kaplan-Meier curves for high-risk and low-risk disease with respect to the presence or absence of any cytogenetic abnormalities (CA). Note that the model is not influenced by CA, implying that GEP high-risk myeloma is a more robust indicator of poor prognosis than the current best prognostic variable.