Schematic illustration of a sequential infusion strategy with CD19 CAR T-cell infusion followed by CD22 CAR T-cell infusion. In this model, the first CAR T-cell infusion provides a first attempt at disease-directed therapy, akin to ALL induction therapy. This is followed by a second CAR T-cell infusion that targets an alternative antigen, which provides consolidation-like therapy to further eradicate disease or help maintain remission. Collectively, the 2 sequential infusions help improve remission durability.