Transplanted HPCs and pGMs give rise to AML after adult MLL-ENL induction. (A) Overview of experiment timeline. (B) Percentage of donor (CD45.2) peripheral blood myeloid cells (CD11b⁺Gr1⁺), B cells (B220⁺), and T cells (CD3⁺) at 4 weeks after transplantation. *P < .05, **P < .01; groups were compared with the 2-tailed Student t test. (C) Kaplan-Meier survival curves for mice transplanted with control or MLL-ENL–expressing bone marrow. (D) Survival curves for a second cohort of MLL-ENL–expressing mice transplanted with 300 000 whole bone marrow cells or 3000 HPCs or pGMs. Group sizes are indicated. Survival curves were compared with the log-rank test.