Figure 6.
Defective platelet aggregate formation in DKO mice. (A) Whole blood anticoagulated with hirudin was perfused through glass capillaries coated with collagen I fibers for 5 minutes at a shear rate of 1500 seconds−1. Scanning electron microscopy images that are representative of at least 3 independent experiments. (B) Aggregation tracings of WT (red) and DKO (blue) washed platelets stimulated with various concentrations of agonists as indicated. Representative of at least 4 independent experiments.