CUX1 mutations and sensitivity to ionizing radiation. (A) Association between integral survival after radiation and CUX1 mutation across 533 cell lines using the information coefficient and as summarized by boxplots (P = .0018; Kolmogorov-Smirnov test). (Right) Black bar represents a mutation in CUX1. CUX1 mutant cell lines were 51. (B) CUX1 inactivation or low expression impacts the accumulation of somatic mutations. Bar graph shows the number of associated mutations in CUX1^MT and CUX1^WT. All mutations were detected by WES in CUX1^MT (n = 3) vs CUX1^WT (n = 117). The Student t test was used to compare groups. (C) Dot blot shows the expression levels of CUX1 in the TCGA AML study (n = 179). Bar graph shows the number of associated mutations in cases with CUX1 low expression (n = 23) vs cases with CUX1 high expression (n = 156). The Student t test was used to compare groups; mean minus SD was used as cutoff.