Kaplan-Meier (KM) curves of EFS by induction failure definition (fail def) D1 to D3, with and without censoring at HCT. KM curves of EFS in CALGB 10201 (A), CALGB 10503 (B), CALGB 10603 (C), CALGB 10801 (D), and CALGB 11001 (E). Green curves represent EFS estimates (est) by D1 (no CR by 60 days after registration/randomization), blue curves represent EFS estimates by D2 (no CR by the end of all protocol-defined induction courses), and red curves represent EFS estimates by D3 (no CR by the end of all protocol-defined treatment). Solid curves represent EFS analysis with censoring at non–protocol-specified HCT, and dashed curves represent EFS analysis without censoring at HCT.