ROTEM analysis of WT, line h38, and FVIII^nullmice whole blood. (A) Whole blood from WT, line h38, and FVIII^null (knockout [KO]) mice were collected via the vena cava vein; ROTEM studies were then performed on those samples. Each curve represents 5 independent studies. (B) Same analysis as panel A; line h38 whole blood was diluted in FVIII^null to result in a 1%, 5%, or 20% level of h38 platelets in the blood mixture. Each curve represents 4 independent studies.