Impact of low-dose IL-2 on naive and memory T-cell compartments. Relative percentages of each subset are shown on the left and absolute (Abs.) cell numbers (cells per microliter) of each subset in the peripheral blood at each time point are shown on the right. Bar graphs on the left show the median percentage of each population and the corresponding median in HDs. Graphs on the right show median cell counts per microliter for each population and the corresponding median in HDs, with the interquartile range (whisker bars). Time points represent weeks (W) and months (M) after IL-2 initiation. Number of patients evaluated at each time point is indicated at the bottom of the image. (A) CD4Treg subsets. *P < .05, **P < .01, each time point was compared with baseline (W0), 2-sided Wilcoxon signed-rank test. (B) CD4Tcon subsets. (C) CD8⁺ T-cell subsets. (D) Proliferation marker (Ki67) expression in CD4Tregs. The percentage of Ki67⁺ cells within naive (orange) and memory (blue) CD4Tregs is shown for HDs and for patients at multiple time points after IL-2 initiation. Median values and the interquartile range (whisker bars) are shown at each time point.