Treatment with AGS-16C3F increased apoptosis of ROSA^{KIT D816V-Gluc}cells in hematopoietic organs and increased survival of mice. Mice were euthanized 4 days after the last injection of AGS-16C3F. (A) Tryptase staining (upper line) and cleaved caspase 3 (lower line) in femur from control ADC or from AGS-16C3F-treated mice. (B) AGS-16C3F prolonged life span of mice. Survival analyses (n = 6 animals/group). Treatment was performed between days 50 and 64, as indicated in the blue box. Statistical difference: P = .02, between the high and low dose of control-treated mice; P < .001 between AGS-16C3F and high- or low-dose control-treated mice independently (log-rank test).