American Society of Hematology

Figure 1.

$Figure 1. PBMC and T-cell donor chimerism following HSCT. (A) Bubble chart demonstrating PBMC and T-cell donor chimerism levels at day 50 posttransplant. The area of each bubble represents the number of events. The first group (n = 37, red), displayed FC, in which both PBMC and T-cell donor chimerism was ≥99%. The second group (MC, n = 32, blue) demonstrated MC in both PBMC and T-cell fractions (PBMC and T-cell chimerism ≤98%). The pattern of PBMC donor chimerism up to day 365 according to donor chimerism at day 50 posttransplant. PBMC chimerism remained stable at complete (or near complete) donor chimerism in patients who demonstrated FC by day 50 posttransplant. In contrast, PBMC donor chimerism remained significantly lower in those found to have MC at day 50, even beyond the initiation of donor lymphocyte infusion (DLI) at day 180 (****P < .0001; 2-way ANOVA, with post hoc Tukey test, mean, and standard error shown for all data points; FC, n = 37; MC, n = 32). (B) The pattern of T-cell donor chimerism up to day 365 according to donor chimerism at day 50 posttransplant. (C) T-cell chimerism remained stable at complete (or near complete) donor chimerism for the first 100 days in patients who demonstrated FC by day 50 posttransplant, but displayed an average drop of 10% by day 180. In contrast, T-cell donor chimerism remained significantly lower in those found to have MC at day 50 with a trend toward partial correction following instigation of DLI at day 180 (****P < .0001, 2-way ANOVA, with post hoc Tukey test, mean, and standard error shown for all data points; FC, n = 37; MC, n = 32).$

PBMC and T-cell donor chimerism following HSCT. (A) Bubble chart demonstrating PBMC and T-cell donor chimerism levels at day 50 posttransplant. The area of each bubble represents the number of events. The first group (n = 37, red), displayed FC, in which both PBMC and T-cell donor chimerism was ≥99%. The second group (MC, n = 32, blue) demonstrated MC in both PBMC and T-cell fractions (PBMC and T-cell chimerism ≤98%). The pattern of PBMC donor chimerism up to day 365 according to donor chimerism at day 50 posttransplant. PBMC chimerism remained stable at complete (or near complete) donor chimerism in patients who demonstrated FC by day 50 posttransplant. In contrast, PBMC donor chimerism remained significantly lower in those found to have MC at day 50, even beyond the initiation of donor lymphocyte infusion (DLI) at day 180 (****P < .0001; 2-way ANOVA, with post hoc Tukey test, mean, and standard error shown for all data points; FC, n = 37; MC, n = 32). (B) The pattern of T-cell donor chimerism up to day 365 according to donor chimerism at day 50 posttransplant. (C) T-cell chimerism remained stable at complete (or near complete) donor chimerism for the first 100 days in patients who demonstrated FC by day 50 posttransplant, but displayed an average drop of 10% by day 180. In contrast, T-cell donor chimerism remained significantly lower in those found to have MC at day 50 with a trend toward partial correction following instigation of DLI at day 180 (****P < .0001, 2-way ANOVA, with post hoc Tukey test, mean, and standard error shown for all data points; FC, n = 37; MC, n = 32).

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