Increased activation of AKT signaling in HMGA2-overexpressing cells. (A) IPA showing cellular functions associated with upregulated or downregulated genes in HMGA2-overexpressing cells. (B) IPA analysis showing cellular pathways enriched in upregulated genes in HMGA2-overexpressing cells. (C) Western blot for the components of the AKT-mTOR pathways in HMGA2-overexpressing cells. Exp., experiment; NO, nitric oxide; ROS, reactive oxygen species.