Efficacy of AAV-mediated rat FVIIa transgene expression in the bleeding phenotype of HA rats. (A) Number of bleeding events exhibited by each animal over the course of the study. Each symbol represents an individual animal. (B) Average number of treatments received during each bleeding event in the HA, HA-AAV <708 (transgene expression in nanograms per milliliter), and HA-AAV ≥708 (transgene expression in nanograms per milliliter) cohorts. *P < .05; **P < .01, using a 1-way ANOVA with Tukey’s multiple comparison test after transformation of data. All data are presented as mean ± SD.