Bleeds in the HA rats. Each image represents a different animal experiencing a bleeding event. (A,F) Rear limb bleeds; (B,G) front limb bleeds (paw and shoulder, respectively); (C,H) lacerations or open wounds; (D,I) eye bleeds; and (E,J) “Other” including internal bleeding and urinary bleeds. Arrows indicate affected areas of the animals. BL, bladder; L, liver; S, spleen; ST, stomach. Animals in E-G and J were euthanized because of reaching ethical endpoints.