BMD quantified by DXA in lumbar spine, femurs, and tibias of skeletally mature male and female WT and F8^TKOmale mice. (A-F) BMD was assessed ex vivo by DXA in 6-month-old male C57BL6 WT and F8^TKO mice in lumbar spine (A), femur (B), and tibia (C) and in 6-month-old female mice in lumbar spine (D), femur (E), and tibia (F). Data are expressed as boxplots (median + IQR) with Tukey whiskers. n = 10 male and female WT and 5 male and 7 female F8^TKO mice/group. ns by Student t test or Mann-Whitney U test (male tibia).