Figure 4.
μCT analysis of femur in skeletally mature WT and F8TKOfemale mice. Six-month-old female C57BL6 WT and F8TKO mice femurs were analyzed by high-resolution (6-µm) µCT for trabecular bone in the distal metaphysis and cortical bone at middiaphysis. (A-H) Trabecular indices (A) BV/TV, (B) BV, (C) TV, (D) Tb.N, (E) Tb.Th, (F) Tb.Sp, (G) TV.D, and (H) SMI. (I) Representative high-resolution (6-µm) 3D visual reconstructions of trabecular bone. Scale bars represent 500 µm. (J-N) Cortical indices (J) Ct.Th, (K) Ct.Ar, (L) Tt.Ar, (M) Ct.Ar/Tt.Ar, and (N) Ct.Po. (O) Representative high-resolution (6-µm) 3D visual reconstructions of cortical bone. Scale bars represent 500 µm. Data are expressed as boxplots (median + IQR) with Tukey whiskers. n = 10 WT and 11 F8TKO mice/group. ***P < .001 and ns by Student t test or Mann-Whitney U test (Tb.Th, Ct.Ar, Tt.Ar, Ct.Ar/Tt.Ar, and Ct.Po).

μCT analysis of femur in skeletally mature WT and F8TKOfemale mice. Six-month-old female C57BL6 WT and F8TKO mice femurs were analyzed by high-resolution (6-µm) µCT for trabecular bone in the distal metaphysis and cortical bone at middiaphysis. (A-H) Trabecular indices (A) BV/TV, (B) BV, (C) TV, (D) Tb.N, (E) Tb.Th, (F) Tb.Sp, (G) TV.D, and (H) SMI. (I) Representative high-resolution (6-µm) 3D visual reconstructions of trabecular bone. Scale bars represent 500 µm. (J-N) Cortical indices (J) Ct.Th, (K) Ct.Ar, (L) Tt.Ar, (M) Ct.Ar/Tt.Ar, and (N) Ct.Po. (O) Representative high-resolution (6-µm) 3D visual reconstructions of cortical bone. Scale bars represent 500 µm. Data are expressed as boxplots (median + IQR) with Tukey whiskers. n = 10 WT and 11 F8TKO mice/group. ***P < .001 and ns by Student t test or Mann-Whitney U test (Tb.Th, Ct.Ar, Tt.Ar, Ct.Ar/Tt.Ar, and Ct.Po).

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