American Society of Hematology

Figure 1.

$Figure 1. μCT analysis of lumbar vertebrae in skeletally mature WT and F8TKO male mice. Six-month-old male C57BL6 WT and F8TKO mice L3 vertebrae were analyzed by high-resolution (6 µm) µCT and independent trabecular and cortical bone compartments segregated. (A-H) Trabecular indices (A) BV/TV, (B) BV, (C) TV, (D) Tb.N, (E) Tb.Th, (F) Tb.Sp, (G) volumetric density (TV.D), and (H) SMI. (I) Representative high-resolution (6-µm) 3D visual reconstructions of L3 vertebrae. Scale bars represent 500 µm. (J-N) Cortical indices (J) Ct.Th, (K) Ct.Ar, (L) Tt.Ar, (M) Ct.Ar fraction (Ct.Ar/Tt.Ar), and (N) cortical porosity (Ct.Po). All data are expressed as boxplots (median + IQR) with Tukey whiskers. n = 10 WT and 11 F8TKO mice/group. *P < .05, **P < .01, ***P < .001, ****P < .0001, and ns (not significant) by Student t test or Mann-Whitney U test (Tb.N and Ct.Ar/Tt.Ar).$

μCT analysis of lumbar vertebrae in skeletally mature WT and F8^TKOmale mice. Six-month-old male C57BL6 WT and F8^TKO mice L3 vertebrae were analyzed by high-resolution (6 µm) µCT and independent trabecular and cortical bone compartments segregated. (A-H) Trabecular indices (A) BV/TV, (B) BV, (C) TV, (D) Tb.N, (E) Tb.Th, (F) Tb.Sp, (G) volumetric density (TV.D), and (H) SMI. (I) Representative high-resolution (6-µm) 3D visual reconstructions of L3 vertebrae. Scale bars represent 500 µm. (J-N) Cortical indices (J) Ct.Th, (K) Ct.Ar, (L) Tt.Ar, (M) Ct.Ar fraction (Ct.Ar/Tt.Ar), and (N) cortical porosity (Ct.Po). All data are expressed as boxplots (median + IQR) with Tukey whiskers. n = 10 WT and 11 F8^TKO mice/group. *P < .05, **P < .01, ***P < .001, ****P < .0001, and ns (not significant) by Student t test or Mann-Whitney U test (Tb.N and Ct.Ar/Tt.Ar).

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