RUNX1mut vs AML1-ETO. (A) Genomic distribution of RUNX1mut, AML1-ETO, and AML1-EVI1 binding sites. All peaks are assigned to promoters (2 kb away from TSS), exons, introns, and intergenic regions based on the physical distance. The priority rule of category assignment: promoter > exon > intron > intergenic region. (B) Gene overlap of RUNX1mut, AML1-ETO, and AML1-EVI1 binding sites selected by +5 kb, −1 kb distance. (C) Differential expression of RUNX1mut and AML1-ETO iPSC. Several significant genes regulated by RUNX1 or AML1-ETO are highlighted. (D) Differential binding of RUNX1 in RUNX1mut and AML1-ETO primary AML samples. (E) Differential expression between 4 RUNX1mut AMLs and 3 AML1-ETO AMLs. (F) Biological processes enriched for genes upregulated in RUNX1mut AMLs compared with AML1-ETO AMLs.