Switchover between L-CD34^−/+LSK and L-GMP cells. L-CD34⁻LSK, L-CD34⁺LSK, and L-GMP cells were isolated from primary AML mice (HSC1:MA9) and transplanted into sublethally irradiated recipient mice individually. When the recipient mice developed leukemia (secondary leukemia), BM cells were analyzed. L-CD34⁻LSK (A), L-CD34⁺LSK (B), and L-GMP (C) cells gave rise to all L-CD34⁻LSK, L-CD34⁺LSK, and L-GMP cells.