Figure 1.
![Figure 1. The global methylation pattern of HCL differs from other indolent B-cell tumors and normal B-cell subpopulations. (A) Unsupervised hierarchical clustering (Euclidean distance, complete linkage). (B) Multidimensional scaling plot showing a 2-dimensional projection of distances across the different histotypes within the series. Methylation profiling (histotype_Meth) included HCL, naive B cells (preGC_Bcell), GC founder B cells (B cells upon antigen encountering, GCfounder_Bcell), low-, intermediate-, and high-maturity memory B cells (loMat_postGC_Bcell, inMat_postGC_Bcell, and hiMat_postGC_Bcell, respectively), splenic MGZ B cells (MGZ_Bcell), CLL samples (U-CLL IGHV, M-CLL IGHV, IGHV3-21+ [CLL–VH3-21]), and SMZL.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/3/3/10.1182_bloodadvances.2018024059/2/advances024059f1.png?Expires=1722723140&Signature=XbxyxgEU1QvDKxgmfgyowtrDe2HvEEW-cIQaAPjAkMM~IBfQQrEEGn4boXCjQ16BqExGNLzUz9wadHQN0O8fpXPfeBcfwgeLULTY16tsyt3lVUGqLHsoyVAXIfnujdWmiE3MC-arl4fbn~EL1YWRQHUWhib9rgwS5ZCMWFMQjXasNf7RckqZipl2BCLnAd6BizHKpFZbv6WPaw4Z8bvSB94bP5LcvW9yOoPhWg54IqAStv~Ro-DIaaxu1jJTBs7hIzAcMVLcOYyJa14hCwBiaH-aiaig5-cLBIynnwsS7Pwvwyfht~fi3zZKhLUbH9vorGsbrrnk6CYAwURzzZrmGg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The global methylation pattern of HCL differs from other indolent B-cell tumors and normal B-cell subpopulations. (A) Unsupervised hierarchical clustering (Euclidean distance, complete linkage). (B) Multidimensional scaling plot showing a 2-dimensional projection of distances across the different histotypes within the series. Methylation profiling (histotype_Meth) included HCL, naive B cells (preGC_Bcell), GC founder B cells (B cells upon antigen encountering, GCfounder_Bcell), low-, intermediate-, and high-maturity memory B cells (loMat_postGC_Bcell, inMat_postGC_Bcell, and hiMat_postGC_Bcell, respectively), splenic MGZ B cells (MGZ_Bcell), CLL samples (U-CLL IGHV, M-CLL IGHV, IGHV3-21+ [CLL–VH3-21]), and SMZL.