Clonal architecture and hierarchy of TET2^MTin biTET2ⁱ. (A) Plot showing dominant, codominant, and secondary mutations in the 82 biTET2ⁱ patients. Mutated gene names, cytogenetics, and diagnosis are color coded as indicated. For this presentation, only genes mutated ≥3 times among the biTET2ⁱ population are represented. Each column represents 1 patient, and each row corresponds to 1 gene or family of genes. (B) Pie chart displaying the percentage of first-hit TET2 occurring as dominant (ancestral), codominant (ancestral), and subclonal (secondary) in the biTET2ⁱ population. (C-E) The bar graphs show the percentages of the corresponding dominant genes to the secondary/subclonal first-hit TET2 gene (C), secondary clones to the dominant first-hit TET2 gene (D), and codominant genes to the codominant first-hit TET2 gene (E). (F) Frequency (in percentage) of mutations in selected genes in the population. Ten genes that are frequently mutated in myeloid neoplasms were selected. Columns are color coded per TET2^MT configuration (TET2^WT, monoTET2^MT, and biTET2ⁱ).