Integration of cytogenetic and CNA subgroups using the 3239 patients in the iBFM cohort reveals a new genetic risk classification. (A) EFS of the 9 subgroups derived from cross-tabulating the 3 cytogenetic and 3 CNA risk groups. (B) Visualized inspection of these curves reveals 4 overall genetic risk groups. (C) EFS of the revised genetic risk groups, which are significantly different from one another.