Outcome of 3239 patients in the iBFM cohort stratified by the UKALL-CNA classifier. (A-B) Kaplan-Meier survival curves (A) and forest plots depicting the hazard ratio and 95% CI from univariate Cox regression models comparing the EFS for CNA-GR or CNA-PR against CNA-IR (B). Patients in the Israeli National Study were excluded from the forest plot, as no event occurred in the CNA-GR or CNA-IR groups. DCOG, Dutch Childhood Oncology Group.