HoxA9 directly regulates cell cycle control genes. (A) Genomic environment, HoxA9 binding, RNA production, and H3K27ac status of cyclin-dependent kinase 6 (Cdk6), cyclin D1 (Ccnd1), and telomerase RNA component (Terc) loci. The line graph shows transcription rates of these genes in response to HoxA9 activity. (B) Core pathways of transformation by HoxA9.