American Society of Hematology

Figure 5.

$NPM1mutallelic burden and DNMT3A mutation type is not associated with NPM1wtrelapse. (A) The variant allele fraction of NPM1, DNMT3A, TET2, and FLT3-TKD mutations at diagnosis of the indicated cohort. (B) The fraction of DNMT3A R882 mutations at diagnosis for the indicated cohort (n = 22 NPM1mut relapse, n = 9 NPM1wt relapse, NS). (C) At CMR, 11/15 patients in the cohort with NPM1mut relapse showed a persistent DNMT3A mutation and 6/9 in the cohort with NPM1wt relapse. Shown is the fraction of persistent DNMT3A R882 mutations in the respective cohort (NS).$

NPM1^mutallelic burden and DNMT3A mutation type is not associated with NPM1^wtrelapse. (A) The variant allele fraction of NPM1, DNMT3A, TET2, and FLT3-TKD mutations at diagnosis of the indicated cohort. (B) The fraction of DNMT3A R882 mutations at diagnosis for the indicated cohort (n = 22 NPM1^mut relapse, n = 9 NPM1^wt relapse, NS). (C) At CMR, 11/15 patients in the cohort with NPM1^mut relapse showed a persistent DNMT3A mutation and 6/9 in the cohort with NPM1^wt relapse. Shown is the fraction of persistent DNMT3A R882 mutations in the respective cohort (NS).

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