Figure 5.
![Figure 5. Proliferation of WT, miR-146a KO, and miR-146b KO B cells in response to LPS, anti-CD40, and anti-IgM antibody. Splenic B cells (CD19+) were incubated for 48 hours in the presence of media only (none) or the indicated mitogens (0.1, 1, or 10 μg/mL LPS; 0.1, 1, or 5 μg/mL anti-CD40; and 10 μg/mL anti-IgM). Proliferation was measured by [3H]-thymidine incorporation. Data are presented as mean ± SEM. n = 6. *P < .05, **P < .01. cpm, counts per minute.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/2/23/10.1182_bloodadvances.2018017954/8/advances017954f5.png?Expires=1726835080&Signature=hVtk304ngBNWzPCfXQ369z1M5B3v6gl7oTN6m9jV4ghRX0er~Wpa-fd~QJS6lD9ngK6ShnkP2ZK4~i6oQujwfeGaWjnsaJGl77GYGtlXvRP2d-gioPhLBkOSrajHx634ZFMgnDblvtctlhnLnTQW0m587IC0uTHpjhIVT1nQj6rcliU2ByIRtoKgQrCbdiSRZrNWQE1C3V7AH76oFq1LArEOrT7933tWFhY~tVZDgObxRL5mb0QyoFu9oi68LcCOjjscgZZwQ3GhSaAHSDmkS5YyIf0bElq2pP7JsUPCMb7uZk8yjWnLdocCjaMhb3O1pV3qVZV8n4UVwE7OlqAFOQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Proliferation of WT, miR-146a KO, and miR-146b KO B cells in response to LPS, anti-CD40, and anti-IgM antibody. Splenic B cells (CD19+) were incubated for 48 hours in the presence of media only (none) or the indicated mitogens (0.1, 1, or 10 μg/mL LPS; 0.1, 1, or 5 μg/mL anti-CD40; and 10 μg/mL anti-IgM). Proliferation was measured by [3H]-thymidine incorporation. Data are presented as mean ± SEM. n = 6. *P < .05, **P < .01. cpm, counts per minute.