miR-146a and miR-146b induction in response to LPS, anti-CD40 antibody, and anti-IgM antibody treatment in splenic B cells. Quantitative RT-PCR analysis of mature miR-146a and miR-146b expression in WT splenic B cells in response to 10 μg/mL anti-IgM antibody (A), 1 μg/mL LPS (B), and 0.1 μg/mL anti-CD40 antibody (C). Mature miR-146a and miR-146b expression was normalized to that of snoRNA202. Data are presented as mean ± standard error of the mean (SEM); n = 3. *P < .05, **P < .01, ***P < .001, ****P < .0001.