Survival data. (A) Survival data in 150 molecularly annotated Mayo Clinic patients with SM (107 advanced, 43 indolent/smoldering) stratified by the presence or absence of adverse mutations. (B) Survival data in 107 molecularly annotated Mayo Clinic patients with advanced SM, stratified by the presence or absence of adverse mutations. (C) Survival data in 65 molecularly annotated patients with SM (10 advanced, 55 indolent/smoldering) seen at the University of Florence, Italy, stratified by the presence or absence of adverse mutations.