Analysis of HDAC6 expression in CLL patient samples. (A) Intracellular HDAC6 protein expression in CD19⁺ CD5⁻ B cells from normal donors (n = 13) and CD19⁺ CD5⁺ B cells from CLL patient peripheral blood samples (n = 38), as determined by flow cytometry. (B) Correlation analyses showing relationship between HDAC6 protein expression and CLL B-cell percentages in CLL patient samples. (C) HDAC6 protein expression in CD38⁺ or CD38⁻ CLL patient samples. Error bars correspond to standard deviations. *P < .05, **P < .005. MFIR, median fluorescence intensity ratio (value normalized to isotype control).