Unique transcriptional signatures discriminate CD16⁺from CD16⁻MDDCs. Shown are top-differentially expressed genes in CD16⁺ vs CD16⁻ MDDCs at immature stage or on exposure to LPS and HIV. Selected top-modulated genes encode for transcriptional factors, surface markers, adhesion molecules, chemotaxis, cytokines, functional markers, HIV interactors, LPS response, and HIV response. Transcripts in bold were validated at RNA and/or protein level in Figure 6.