Differential gene expression in CD16⁺and CD16⁻MDDCs in response to HIV. Transcriptional profiling was performed as described in Figure 1A,G-H, with matched MDDCs subsets exposed to media (immature) or HIV for 24 hours. Shown are top differentially regulated genes in immature and HIV-exposed CD16⁺ (green) and CD16⁻ MDDCs (pink) (A) and differentially expressed genes in CD16⁺ (green) vs CD16⁻ (blue) MDDC subsets exposed to HIV (P < .05; FC cutoff, 1.3) linked to the gene ontology terms exosome (B). Heat map cells are scaled by the expression-level z-scores for each probe individually. Results were generated with cells from 5 different donors identified with different color codes.