Analysis of covariance for the bone mineral density percentage change, defined as the dependent variable, with treatment group as a factor, defined as the independent variable consisting of 2 levels (DNM and placebo), and first baseline T score as covariate or nuisance variable. A significant difference on the percentage change (from baseline to 12-month visit) between the 2 groups was observed, after adjusting for the baseline T score (P = .043). DNM induced a significantly greater increase in bone mineral density compared with placebo.