Macrophage infusion rescued intravascular hemolysis of Hmox1 KO mice. (A) Serum hemopexin, (B) liver hemopexin mRNA levels, (C) serum haptoglobin, (D) liver haptoglobin mRNA levels, (E) serum LDH and (F) ALP activity of WT and Hmox1 KO mice before and after macrophage infusion for 12 weeks. (G) RBC fragments in the WT and Hmox1 KO group with or without macrophage infusion. The data were obtained by hematology analyzer and analyzed with FlowJo software. Mean ± SD; statistical analyses were performed using 2-way ANOVA (multiple comparisons). The graphs were created with GraphPad Prism software. *P < .05, **P < .01, ***P < .001, ****P < .0001. n.s, not significant.