SVs in the MYC locus discovered by targeted capture sequencing. The horizontal axis represents genomic space on chromosome 8 (chr8). The upper panel summarizes the whole MYC capture region, and the bottom panel zooms in to the gene region. In each panel, the top track shows the location of translocation breakpoints (vertical ticks on the axis), and partner information is summarized with symbols above. The middle track shows gene models in the region. The bottom track shows the location of intrachromosomal rearrangements, with rectangles representing the span of the rearrangements. Arrows indicate that the end of the rearrangement is located outside of the plotting region at the labeled location. In the upper panel, rearrangements in the genic cluster have been binned for visualization. Additional middle tracks in the upper panel show the approximate location of reported enhancer regions (blue boxes) and the approximate binding location of FISH break-apart probes (green Vysis probe binds downstream of the plotted region). The shaded gray rectangle shows the captured region. Rearrangements that failed validation and low-confidence predictions in nonvalidated cases have been omitted. Intrachromosomal rearrangements smaller than 2 Mb have not been plotted, and rearrangements for which both reciprocal events were identified have only 1 displayed.