Chronic low-dose stimulation of Vav-KDM6B mice led to gene overexpression in BM LSK cells. (A) Heat map of the differentially activated genes in LSK BM cells of LPS-treated Vav-KDM6B mice. (B) Molecular pathways associated with the differentially activated genes in LSK BM cells of LPS-treated Vav-KDM6B mice, as revealed by gene set enrichment analysis. (C) Forty-one of the differentially activated genes in LSK BM cells of LPS-treated Vav-KDM6B mice were overexpressed in CD34-positive BM cells from patients with CMML (N = 20) compared with CD34-positive BM cells of healthy donors (N = 10). Results are based on RNA-Seq in mouse cells and RNA-Seq in human cells.