Schematic representation for role of ASXL1 in regulating osteoclastogenesis. ASXL1 binds to PRC2 proteins to methylate promoters of key osteoclast differentiation genes such as NFATc1 and regulate their expression (left). Absence of ASXL1 prevents PRC2-mediated histone methylation (right). Jmjd3, specific demethylase for H3K27me3 in turn removes K27 methyl groups from promoters such as NFATc1, resulting in increased osteoclastogenesis.