Disease classification model according to 2 mutational indices identified by targeted sequencing. (A) Shown is a hierarchical classification model for 3 disease-enriched subsets including de novo AML, AML-MRC, and MDS based on recursive partitioning analysis. Data from all 44 patients were analyzed to identify the optimal mutational indices that could best segregate patients within these 3 subsets. In each subset generated by partitioning analysis, the enriched diseases are highlighted in blue. (B) Shown is a receiver operating characteristic curve depicting the accuracy of classification based on this model. AUC, area under the curve.