Monocyte LPS-induced cytokine production. (A) TNF-α, (B) IL-10, (C) IL-1β, and (D) IL-8 following exposure of RCC supernatant from different RCC manufacturing methods at fresh (day 5/white) and at expiration (day 42/shaded). Significant level in comparison with control (*P < .05; **P < .01; ***P < .001).