Clearance rate of rhvWf in vWf-deficient mice injected with rhIL-11.

vWf^−/− mice were injected daily with placebo (■) or 250 μg/kg rhIL-11 (▪) for 5 days. We administered 40 U/kg rhvWf intravenously on day 5, and blood was collected from different groups of mice at different time points after vWf injection. Plasma vWf levels were determined and expressed as the percentage of the level at time zero (P > .5 for each time point compared with placebo; n = 3-4).