Effect of rhIL-11 injections in mice heterozygous for vWf.

VWf^+/− mice were injected daily for 7 days with placebo or 250 μg/kg rhIL-11. (A) Platelet counts, (B) vWf level, and (C) FVIII activity were assessed before (■) and after (▪) the treatment. To facilitate comparison, the baseline levels of vWf and FVIII observed in wild type mice are indicated (▨) (n = 9-12). *P < .0075 if compared with placebo-injected mice or to preinjection levels.