Fig. 1.
![Fig. 1. BMP-4 inhibits DNA synthesis in IL-6–dependent myeloma cell lines. / Cell lines were stimulated with 0.1 ng/mL IL-6 (IH-1 and OH-2) or 1 ng/mL IL-6 (ANBL-6), with or without BMP-4, in concentrations as indicated for 72 hours. DNA synthesis was measured by [3H]-thymidine incorporation. Counts were normalized; 100% represents the count obtained with IL-6 alone (absolute counts were 1500 counts per minute (cpm) for IH-1, 2400 cpm for ANBL-6, and 900 cpm for OH-2).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/2/10.1182_blood.v97.2.516/5/h80210582001.jpeg?Expires=1722777027&Signature=LirgygRvrkKm5CngJocJ1fP~5xro7khOkQXk1j0oVCHadvDZGRy9NtKfJ99SDRFzd53DUrbDPWvGg7VSjtfSVdjUvevPaWMKG1zXo2retmnzzCmM63ZxwEoXks8bu5FBsFjmXAz65BhFV5CrUezCrv41rjYWSNDGDpC8bm5Ur92WEyPNixsLrbpkY6HrU0S~mPqZ8w6JqHqTVU07IbGdyoWBFJ3mYe1f7-6H5J-2E7QfDm0FsEcGHNo8hd4YVcEqHmlNxgbNNq5QpEIcaE2afU-XB6aKHnkDZPgw~s6YRxxHhidixTHwIktIqLTgKTneCLHDupKCS6-GkWLTOa2U0w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
BMP-4 inhibits DNA synthesis in IL-6–dependent myeloma cell lines.
Cell lines were stimulated with 0.1 ng/mL IL-6 (IH-1 and OH-2) or 1 ng/mL IL-6 (ANBL-6), with or without BMP-4, in concentrations as indicated for 72 hours. DNA synthesis was measured by [3H]-thymidine incorporation. Counts were normalized; 100% represents the count obtained with IL-6 alone (absolute counts were 1500 counts per minute (cpm) for IH-1, 2400 cpm for ANBL-6, and 900 cpm for OH-2).
