Kaplan-Meier plot of survival for wt and tg mice.

Mean survival of tg mice (n = 26) was significantly reduced to 7.4 months, whereas wt mice (n = 37) had a mean survival of 10.0 months. The observational period was 10.5 months. Cumulative survival was 0.92 ± 0.05 (mean ± SEM) for wt mice in contrast to 0.34 ± 0.08 for tg mice. Survival distribution was significantly different (P < .0001, log-rank test).