Model of type I IFN receptor-ligand interactions in murine thymocytes.

When both receptor components are expressed (A) a full antiproliferative response occurs on stimulation with type I IFN. This response can be partially inhibited by muIfnar-2a (B). No response occurs when only muIfnar-1 (C) is present. However, when muIfnar-1, IFN and muIfnar-2a are present, a partial response is restored (D).