Monensin potentiates the cytotoxic activity of LL2-onconase.

Daudi (A) or Ramos (B) cells were treated with increasing concentrations of LL2-onconase in the absence (solid squares) or presence (open squares) of monensin for 3 days before protein synthesis was measured as described in “Materials and methods.” Monensin concentrations were 1 × 10⁻⁷ M and 1 × 10⁻⁸ M on Daudi and Ramos cells, respectively. Figure is representative of 2 experiments. The SEM of triplicate determinations are shown when they are greater than the symbol.