Skewed distribution of the NPS in patients with CMV reactivation (any DNAemia). (A) The skewed distribution of the NPS (IL-2⁻IFN-γ⁺TNF-α⁻ΜIP-1β⁺ cells within the CMV(pp65)-specific CD8⁺ T-cell compartment) in patients with CMV reactivation, with the highest levels among those individuals with clinically significant CMV. P value for comparision between groups using Mann-Whitney U test. EC (n = 13); SC (n = 16); NC (n = 13). (B) The 100-day cumulative incidence of CMV reactivation (any DNAemia) by levels of NPS, using 5.7% as cutoff. Specific cutoff was identified using the most significant P value approach. Number of subjects in log-rank analysis was 9 and 17 for NPS low and high, respectively.