Figure 6.
Schematic showing altered HMG binding to WT RAG1 and R401W. The DNA strands are shown with the heptamer, spacer, and nonamer indicated. A and B represent the likely positions of HMG Box A and B, respectively, and R1 and R2 represent RAG1 and RAG2. The bend angles within each RSS are shown.

Schematic showing altered HMG binding to WT RAG1 and R401W. The DNA strands are shown with the heptamer, spacer, and nonamer indicated. A and B represent the likely positions of HMG Box A and B, respectively, and R1 and R2 represent RAG1 and RAG2. The bend angles within each RSS are shown.

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