An example of increase of ^99mTc-DTPA uptake after the infusion of NGR-hTNF followed by R-CHOP at the third course of treatment. The volume of ≥30% ^99mTc-DTPA uptake is contoured in 2 SPECT studies performed before (left image, blue line) and after (middle image, green line) administration of NGR-hTNF and R-CHOP. Comparison of contoured volumes are represented in the gadolinium-enhanced T1-weighted MRI showing the tumor (right image). The volume of interest before and after NGR-hTNF/R-CHOP delivery was 22 cm³ and 40 cm³, respectively.