Changes in BBB permeability assessed by DCE-MRI in responders. Changes in the enhanced areas are represented on the left and in the perilesional areas on the right; results are expressed in K^trans. Values at the first course (without NGR-hTNF) and second and sixth courses (with NGR-hTNF) for each patient are linked with a line. Data were suitable for analysis only in patients with responsive disease and measurable residual lesions. Median and range values per subgroup are reported at the bottom of each graphic.