Swimmer plot of responses and duration of responses. The best response to NGR-hTNF/R-CHOP was complete in 8 patients (blue) and partial in 1 patient (green); 3 patients experienced progressive disease (red). Response lasted >6 months in all responders. Six responders experienced relapse (R) at 7 to 12 months; 2 responders (patient #2 and patient #10) died (D) of complications related to progressive neurological impairment, without evidence of relapsing lymphoma. Four patients (#4, #7, #8, and #12) are alive at 27, 19, 19, and 13 months from trial registration. Bars were cut at 16 months for clarity.