Examples of responses to R-CHOP preceded by NGR-hTNF. (A) Gadolinium-enhanced T1 weighted scan shows a large homogeneous enhancing lesion in the left frontal lobe (arrows) in a 62-year-old woman at the second relapse after high-dose methotrexate and after salvage high-dose ifosfamide-based therapy; disease was refractory to previous lines. (B) Tumor regression after 2 courses of experimental treatment. (C) Gadolinium-enhanced T1 weighted scan shows a large enhancing left temporal lesion (arrows) in a 65-year-old man at the second relapse after high-dose methotrexate and after salvage whole-brain irradiation. (D) Tumor regression after 2 courses of experimental treatment.